What Are the Benefits of Taking CBD Oil? CBD can interfere negatively with certain medications. These include benzodiazepine tranquilizers such as Klonopin (clonazepam) and anti-immunosuppressants such as Sandimmune(cyclosporine) and benzodiazepine serotonins. It can also increase levels of blood thinners, such as warfarin. The early research suggests that CBD could